CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury
نویسندگان
چکیده
Alicia N. Rizzo, Saad Sammani, Adilene E. Esquinca, Jeffrey R. Jacobson, Joe G. N. Garcia, Eleftheria Letsiou, and Steven M. Dudek University of Illinois Hospital and Health Sciences System, Division of Pulmonary, Critical Care, Sleep and Allergy, Chicago, Illinois; University of Illinois at Chicago, Department of Pharmacology, Chicago, Illinois; Arizona Health Sciences Center, University of Arizona, Tucson, Arizona
منابع مشابه
Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), an illness characterized by life-threatening vascular leak, is a significant cause of morbidity and mortality in critically ill patients. Recent preclinical studies and clinical observations have suggested a potential role for the chemotherapeutic agent imatinib in restoring vascular integrity. Our prior work demonstrates differe...
متن کاملCALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury
Letsiou E, Rizzo AN, Sammani S, Naureckas P, Jacobson JR, Garcia JG, Dudek SM. Differential and opposing effects of imatinib on LPSand ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 308: L259–L269, 2015. First published December 5, 2014; doi:10.1152/ajplung.00323.2014.—Endothelial dysfunction underlies the pathophysiology of vascular disorders such as acute lung injury (ALI)...
متن کاملDifferential and opposing effects of imatinib on LPS- and ventilator-induced lung injury.
Endothelial dysfunction underlies the pathophysiology of vascular disorders such as acute lung injury (ALI) syndromes. Recent work has identified the Abl family kinases (c-Abl and Arg) as important regulators of endothelial cell (EC) barrier function and suggests that their inhibition by currently available pharmaceutical agents such as imatinib may be EC protective. Here we describe novel and ...
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Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
متن کاملPositive Expiratory Pressure (PEP) versus Conventional Chest Physiotherapy in Pediatric Patients with Acute Exacerbation of Cystic Fibrosis
Background Pulmonary involvement is the main cause of mortality in cystic fibrosis (CF). Airway clearance techniques are non-pharmacological complement options for CF patients. The aim of this study was to evaluate the short-term outcome of airway cleaning treatment in patients with cystic fibrosis in a children's hospital. Materials and Methods This clinical trial study conducted on 40 CF pati...
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تاریخ انتشار 2015